Key West to Gainesville
Regional driving route
How Long Is the Drive from Key West to Gainesville?
The drive from Key West to Gainesville takes approximately 8h 20m, covering 459 miles via the highway. Under normal conditions, expect to spend around $53 on gas.
Travel time can vary — during peak hours, weekends, or holidays, the journey may take 11–12+ hours. For the fastest trip, leave early morning (before 7 AM) or travel on weekday evenings.
Traffic Estimate
Traffic is usually worst during weekday rush hours (7–9 AM, 4–7 PM) and holiday weekends.
Route Details
Cost Breakdown
Route Tips: I-75
Plan rest stops every 2-3 hours on longer drives. Check traffic conditions before departure and keep your tank above quarter-full.
This trip can typically be done on a single tank of gas.
Best Time to Drive from Key West to Gainesville
For a long drive like Key West to Gainesville, plan to depart early in the morning. This lets you cover most of the distance before afternoon traffic builds up. Consider breaking the trip with a lunch stop midway.
Driving vs Flying
✈️ Flying is faster when you factor in airport time. Flight time is ~55 min but add ~2.5 hours for check-in, security, and boarding.
All Travel Options
Estimated times and prices. Bus/train availability varies by route. Driving gives the most flexibility for stops and schedules.