Gainesville, FL

Driving from Gainesville, FL: What to Know

Gainesville, FL sits in Florida, in the Southeast, and most trips out of town start on the local highway network before joining the interstate system. Fill up before you leave — fuel is usually cheaper in town than at highway service plazas — and check conditions before longer drives, since weather in the Southeast can change travel times considerably. The main corridor for trips listed on this page is I-95, so check for construction or closures on that route before setting out.

All drive times on this page assume normal conditions. Gas cost estimates use a 30 MPG vehicle at current average fuel prices — a hybrid or EV can cut that cost roughly in half, and you can compare electric options on our EV trip pages.